硫酸反苯环丙胺 标准品
Tranylcypromine hemisulfate(TRANS-2-PHENYLCYCLOPROPYLAMINE HEMISULFATE SALT)
CAS: 13492-01-8
化学式: C9H13NO4S
| 中文名 | Tranylcypromine hemisulfate |
| 英文名 | TRANS-2-PHENYLCYCLOPROPYLAMINE HEMISULFATE SALT |
| 别名 | 硫酸反苯环丙胺 反苯环丙胺半硫酸盐 硫酸反苯环丙胺 标准品 反-2-苯基环丙基胺半硫酸盐 反式-2-苯基环丙胺 半硫酸盐 TRANYLCYPROMINE硫酸盐 |
| 英文别名 | tranylcyprominesulfate tranylcyprominesulphate TRANYLCYPROMINE HEMISULFATE Tranylcypromine hemisulfate Tranylcypromine Sulfate (125 mg) TRANS-2-PHENYLCYCLOPROPYLAMINE HEMISULFATE (1R,2S)-rel-2-Phenylcyclopropanamine Sulfate TRANS-2-PHENYLCYCLOPROPYLAMINE HEMISULFATE SALT rel-(1R,2S)-2-phenylcyclopropan-1-amine hemisulfate |
| CAS | 13492-01-8 |
| EINECS | 236-807-1 |
| 化学式 | C9H13NO4S |
| 分子量 | 231.27 |
| InChIKey | BKPRVQDIOGQWTG-FKXFVUDVSA-N |
| 溶解度 | 易溶于水; 极微溶于乙醇 (96%) 和乙醚。 |
| 存储条件 | 15-25°C |
| 稳定性 | 从提供的购买之日起稳定1年。蒸馏水中的溶液可以在-20 ° 下储存长达3个月。 |
| 外观 | 白色固体。 |
| 颜色 | White |
| 体外研究 | Tranylcypromine (10 nM to 10 µM) exerts neuroprotective effects against toxicity induced by human Aβ(1-42) oligomers independently from the presence of glial cells. Tranylcypromine (100 μM) significantly protects RGCs from glutamate neurotoxicity-induced apoptosis as well as apoptosis induced by oxidative stress. Tranylcypromine promotes mitogen-activated protein kinase 12 (p38 MAPKγ) expression under conditions of glutamate (Glu)-induced stress. Besides, tranylcypromine contributes to RGC survival via alterations of p38 MAPKγ activity. |
| 体内研究 | Tranylcypromine treatment significantly and substantially reduces the lesion size and improves generalized hyperalgesia in a dose-dependent fashion in mice with induced endometriosis. In addition, tranylcypromine treatment results in reduced immunoreactivity to biomarkers of proliferation, angiogenesis, and H3K4 methylation, leading to arrested EMT and lesion growth. Tranylcypromine (500 mM) injection exerts neuroprotective effects within intracellular apoptotic signaling pathways and suppresses morphologic changes in the retina of the rat, suppresses caspase 3 activity and recovers p38 MAPKγ expression in the retina after NMDA-induced injury, and enhances RGC survival after retinal injury via the attenuation of NMDA neurotoxicity. Tranylcypromine (10 µg/g) causes an approximate and significant doubling of labeled cells in the combined brain regions examined, as detected by BrdU immunohistochemistry. Tranylcypromine causes the greatest increase in cell proliferation in the cerebellum. |
| 危险品标志 | T - 有毒物品 |
| 风险术语 | 23/24/25 - 吸入、皮肤接触及吞食有毒。 |
| 安全术语 | S36/37/39 - 穿戴适当的防护服、手套和护目镜或面具。 S45 - 若发生事故或感不适，立即就医(可能的话，出示其标签)。 |
| 危险品运输编号 | UN 2811 6.1/PG 2 |
| WGK Germany | 3 |
| RTECS | GZ2625000 |
| 海关编号 | 2921490002 |
| Hazard Class | 6.1(b) |
| Packing Group | III |
| 上游原料 | 重氮乙酸乙酯 氯化亚砜 氢氧化钠 盐酸 苯乙烯 |
| 参考资料 展开查看 | 1: Gahr M, Schönfeldt-Lecuona C, Kölle MA, Freudenmann RW. Intoxications with the monoamine oxidase inhibitor tranylcypromine: an analysis of fatal and non-fatal events. Eur Neuropsychopharmacol. 2013 Nov;23(11):1364-72. doi: 10.1016/j.euroneuro.2013.05.009. Epub 2013 Jun 19. Review. PubMed PMID: 23791433. 2: Krings-Ernst I, Ulrich S, Adli M. Antidepressant treatment with MAO-inhibitors during general and regional anesthesia: a review and case report of spinal anesthesia for lower extremity surgery without discontinuation of tranylcypromine. Int J Clin Pharmacol Ther. 2013 Oct;51(10):763-70. doi: 10.5414/CP201898. Review. PubMed PMID: 23993253. 3: Gahr M, Schönfeldt-Lecuona C, Kölle MA, Freudenmann RW. Withdrawal and discontinuation phenomena associated with tranylcypromine: a systematic review. Pharmacopsychiatry. 2013 Jun;46(4):123-9. doi: 10.1055/s-0032-1333265. Epub 2013 Jan 28. Review. PubMed PMID: 23359339. 4: Iwersen S, Schmoldt A. One fatal and one nonfatal intoxication with tranylcypromine. Absence of amphetamines as metabolites. J Anal Toxicol. 1996 Sep;20(5):301-4. Review. PubMed PMID: 8872238. 5: Baker GB, Coutts RT, McKenna KF, Sherry-McKenna RL. Insights into the mechanisms of action of the MAO inhibitors phenelzine and tranylcypromine: a review. J Psychiatry Neurosci. 1992 Nov;17(5):206-14. Review. PubMed PMID: 1362653; PubMed Central PMCID: PMC1188458. |
硫酸反苯环丙胺 标准品 - 配置溶液浓度参考
| 1mg | 5mg | 10mg | |
|---|---|---|---|
| 1 mM | 2.744 ml | 13.719 ml | 27.438 ml |
| 5 mM | 0.549 ml | 2.744 ml | 5.488 ml |
| 10 mM | 0.274 ml | 1.372 ml | 2.744 ml |
| 5 mM | 0.055 ml | 0.274 ml | 0.549 ml |
最后更新：2024-01-02 23:10:35
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产品名: Tranylcypromine hemisulfate 去供应商网站查看 询盘CAS: 13492-01-8
产地: 中国上海
包装: 100mg
规格: 99%
价格: 68.00
库存: 现货
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产品描述: 中文名：Tranylcypromine hemisulfate 英文名:TRANS-2-PHENYLCYCLOPROPYLAMINE HEMISULFATE S 更多
现货供应
产品名: Tranylcypromine hemisulfate 去供应商网站查看 询盘CAS: 13492-01-8
产地: 上海
规格: T883087
价格: 100mg-85,250mg-169,1g-509
库存: 现货
电话: 13816333479/13918391375
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现货供应
产品名: Tranylcypromine hemisulfate 去供应商网站查看 询盘CAS: 13492-01-8
产地: 上海
规格: 99%
价格: 100mg 255,1g 750,5g 1690
库存: 现货
电话: 18301782025
手机: 18301782025
电子邮件: 3008007403@qq.com
QQ: 3008007403
微信: 18301782025
产品描述: Tranylcypromine hemisulfate 99% MedMol 货号：S82931
现货供应
产品名: Tranylcypromine hemisulfate 去供应商网站查看 询盘CAS: 13492-01-8
产地: 中国上海
包装: 100mg
规格: 99%
价格: 68.00
库存: 现货
电话: 400-900-4166
手机: 18017137653
电子邮件: 3007523013@qq.com
QQ: 3007523013
微信: 18017137653
产品描述: 中文名：Tranylcypromine hemisulfate 英文名:TRANS-2-PHENYLCYCLOPROPYLAMINE HEMISULFATE S 更多
现货供应
产品名: Tranylcypromine hemisulfate 去供应商网站查看 询盘CAS: 13492-01-8
产地: 上海
规格: T883087
价格: 100mg-85,250mg-169,1g-509
库存: 现货
电话: 13816333479/13918391375
手机: 13816333479/13918391375
电子邮件: wangrui@macklin.cn
QQ: 2885703204/285395191
微信: 19863730987/13918391375
现货供应
产品名: Tranylcypromine hemisulfate 去供应商网站查看 询盘CAS: 13492-01-8
产地: 上海
规格: 99%
价格: 100mg 255,1g 750,5g 1690
库存: 现货
电话: 18301782025
手机: 18301782025
电子邮件: 3008007403@qq.com
QQ: 3008007403
微信: 18301782025
产品描述: Tranylcypromine hemisulfate 99% MedMol 货号：S82931
硫酸反苯环丙胺 标准品的上游原料
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